General:
LC/MS/MS target compound quantification
LC/high resolution MS/MS for compound-impurity- metabolite or degradation product identification
LC/UV analysis and purity determination
LC/fluorescence analysis
ELISA determinations
Bioassay measurements using chemiluminescence or fluorescence probes.

Facility and equipment testing for cross-contamination 

1. Swabbing LC/MS/MS approach is used to detect pharmaceutical products and food allergens in facility and machine surfaces.
2. Developed chemical indicators to verify decontamination procedure was successful.
3. Have methods developed for detection of  b-lactams, cyclosporine’s, steroids, benzodiazepines and food products including peanut, tree nuts wheat, barley and rye.
4. Swabbing surfaces with LC/MS/MS analysis to determine pharmaceutical and antibiotic  residues and cross contamination.

Preclinical and early discovery- metabolite ID, PKDM

1.  Develop and validate LC-MS/MS assays for measuring small molecule drugs and proteins biologics in biological matrices (including plasma, serum, urine, muscle, heart, lung kidney and liver).
2. Identify metabolites in-vivo and in-vitro in biological matrices.
3. Work with clients to provide analytical data for meeting goals set by the funders and provide data to support IND filings.

Detection  and identification of impurities and degradation products in formulations or manufactured products

1. Identify and quantitation of leachable and extractables from medical devices in accordance to ISO 10993-18, to support the joint program with 2SD Toxicology Services verifying the Biocompatibility of Medical Devices and components that make up these devices.
2. Identification and quantitation of forced degradation products from hydrolysis (acid–base) , photolysis, thermal, oxidation from drug substances and drug products.
3. Stability studies on drug substances and drug products, according to ICH guidelines at 40C, 25C, -20C and -80C and identifying and quantifying the products detected.
4. Determine drug potency by bioassays during stability study and after forced degradation studies.

Proteomics:

1. Enzymatic digestion and LC/MS/MS analysis for protein identification, quantification and disulfide bond location.
2. Identify and measure allergenic proteins and to test ability of new drugs to degrade allergens.
3.  Use of enzymatic digestion and LC-MS/MS to detect marker peptides representing allergenic proteins for  wheat, barley, rye, soy, peanuts,  tree nuts, milk, egg, celery and mustard in food products.
4. Provide food authenticity analysis.