Electrophysiology Bioassay for CFTR-Targeting Botanical Drug

We’re seeking contract laboratory support to develop or transition to a cost-effective electrophysiology-based bioassay for a commercial botanical drug product. The current assay utilizes Ussing chambers with a monolayer of CFTR-expressing cells to evaluate drug interaction via ion current modulation. Due to rising costs, we’re exploring alternative assay platforms that maintain sensitivity and specificity for CFTR channel activity, suitable for both release and stability testing.